bioRxiv · Bioinformatics· Lotz, M., Swahn, H., Sakamoto, T., Kenvisay, C., Olmer, M., Uchida, Y., Asahara, H., Miller, R. E., Malfait, A.-M., Orange, D. E., Mehta, B., Otero, M., Bugbee, W. D. ·· 1 天前AI 评分43
人软骨转录组与表观基因组整合分析揭示骨关节炎进展中FN1表达、剪接及受体信号的协同变化
Integrated transcriptomic and epigenomic profiling of human cartilage reveals coordinated changes in fibronectin expression, splicing, and receptor signaling during osteoarthritis progression
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人膝关节软骨转录组与表观基因组整合分析揭示，骨关节炎进展中FN1表达、剪接和受体信号发生协同变化。分析覆盖92个膝关节、30名供者的108,600个软骨细胞核及24名供者的单核多组学数据。随OA分级上升，ECM生成增强、稳态程序减弱，FN1受体使用由integrin α5β1转向CD44及较弱地转向αvβ8。
来源：bioRxiv · Bioinformatics · biorxiv.org