medRxiv · All· Padhi, E. M., Kiernan, E. A., Nguyen, J. V., DeGorter, M. K., Rosa, V. S., Mostovoy, Y., Yenkin, A. L., Su, H., Lichtenstein, L., Marderstein, A. R., Gillard, J., Baalawi, W., Parsa, S. J., Cicek, M. S., Meyer, J. G., Blegen, A. L., McNally, V. A., Lane, J. J., Fredericksen, Z. S., All of Us Research Program Multi-omics Working Group,, The All of Us Research Program,, Gupta, N., Brand, H., Garimella, K., Karczewski, K. J., Talkowski, M. E., Lennon, N. J., Montgomery, S. B. ·· 2 天前AI 评分50
All of Us Research Program 多组学队列扩展健康与疾病遗传机制图谱
Multi-omics in the All Of Us Research Program expands mapping genetic mechanisms in health and disease
AI 导读
All of Us Research Program 多组学队列检出 182,246 个 QTL，其中 54,255 个精细定位至罕见变异。罕见变异效应更可能具祖源限制性，并影响已知孟德尔病基因（OR = 1.4）和获批药物靶点（OR = 1.3）；数据通过 All of Us Research Hub 分层开放。
来源：medRxiv · All · medrxiv.org