bioRxiv · Bioinformatics· Munir, Y. A., Sagir, U., Sajjad, F., Khurshid, S., Tarique, F., Sani, I. M. ·· 2 天前AI 评分32
前额叶皮层转录组区分阿尔茨海默病、无症状淀粉样病理、神经肽缺失、免疫补体激活与胶质重塑
Prefrontal cortex transcriptomes distinguish Alzheimers disease from asymptomatic amyloid pathology, neuropeptide loss, immune-complement activation and glial remodelling
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研究重分析15名供体DLPFC bulk RNA-sequencing数据，发现AD与正常对照、病理老化相比分别有341和496个差异表达基因。AD中神经肽和激素信号基因下调，免疫干扰素-γ反应、髓系细胞及经典补体通路上调，并出现胶质发生、少突胶质细胞分化与髓鞘化重塑。
来源：bioRxiv · Bioinformatics · biorxiv.org