bioRxiv · Cancer Biology· Haselager, M. V., Lashgari, D., Jongejan, A., Roos, J. L., Dijkema, M., Dubois, J., Peters, F. S., Kater, A. P., Moerland, P. D., Eldering, E. ·· 1 天前AI 评分43
3D CLL 球体模型的单细胞解析：再现淋巴结微环境驱动表型与体内伊布替尼反应
Single-cell characterization of 3D CLL spheroid model that recapitulates lymph node microenvironment-driven phenotypes and in vivo drug responses to ibrutinib
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研究团队用单细胞 RNA 测序分析患者来源 CLL 球体及配对外周血、淋巴结样本，识别静息、活化、增殖 3 种状态。伊布替尼
来源：bioRxiv · Cancer Biology · biorxiv.org