GEO 数据集

主题由标题与摘要自动归类；样本量为数据集标注之和，SuperSeries 可能与其 SubSeries 重复计算。

• Age-associated hsa_piR_020485 inhibits osteogenic differentiation of bone marrow stromal cells and promotes macrophage migration
  GSE351871Rattus norvegicus6 个样本2026-10-31

  Age-related decline in bone marrow stromal cell (BMSC) function and inflammatory changes contribute to osteoporosis. We investigated the age-associated PIWI-interacting RNA hsa_piR_020485 and its effects on BMSC function, macrophage responses, and trabecular bone volume fraction.
• Transciptomics analysis: the role of chronic ethanol feeding in promoting dysfunction of stromal vascular cells from rat viceral adipose tissue
  GSE312640Rattus norvegicus8 个样本2026-10-31

  Chronic ethanol exposure induces adipose tissue dysfunction. Rats are divided into 2 groups: CONT and ET. The study aim to determine the role of stromal vacular cells (SVC) in mediating viceral adipose tissue (VAT) dysfunction in alcohol-associated liver disease.
• RNA sequencing to compare SAIPS-PAI0 group with VIPS-PAI group
  GSE309777Rattus norvegicus2 个样本2026-10-31

  14 days after the VIPS-PAI and SAIPS-PAI0 scaffolds were implanted in the rat femoral defect models, tissues surrounding and within the scaffolds were harvested from both groups for RNA sequencing to analyze the gene expression profiles.
• Microglia Secrete MiR-146a-5p-Containing Exosomes to Regulate Neurogenesis in Depression
  GSE185777Rattus norvegicus6 个样本2026-10-31

  Enhancing neurogenesis within the hippocampal dentate gyrus is critical for maintaining brain development and function in many neurological diseases. However, the neural mechanisms underlying neurogenesis in depression remain unclear. Here, we show that microglia transfer a microglia-enriched microRNA, miR-146a-5p, via secreting exosomes to inhibit neurogenesis in depression. Overexpression of miR-146a-5p in hippocampal dentate gyrus (DG) suppresses neurogenesis and spontaneous discharge of excitatory neurons by directly targeting Krüppel-like factor 4 (KLF4). Down-regulation of miR-146a-5p expression, ameliorates adult neurogenesis deficits in DG regions and depression-like behaviors in rats. Intriguingly, circular-RNA ANKS1B acts as a miRNA sequester for miR-146a-5p to mediate posttranscriptional regulation of KLF4 expression. Collectively, these results indicate that miR-146a-5p can function as a critical factor regulating neurogenesis under conditions of pathological processes resulting from depression and suggest that microglial exosomes generate new cross-talk channels between glial cells and neurons.
• Transcriptomic profiling of primary rat nucleus pulposus cells cultured in soft and stiff GelMA hydrogels
  GSE344937Rattus norvegicus6 个样本2026-10-30

  This study profiles gene expression in primary rat nucleus pulposus cells encapsulated in 10% GelMA hydrogels with either 30% or 60% methacryloyl substitution. Three independent biological replicates were sequenced for each matrix condition.
• scRNAseq analysis of rat dorsal root ganglions from different peripheral injury treatment; a nerve transection, a crush 2 weeks after the cut and a resection of the neuroma 2 weeks afrer the initial cut
  GSE315353Rattus norvegicus6 个样本2026-10-30

  Peripheral nerve injury, whether caused by a cut, crush, or excessive stretch, can result in the formation of a painful neuroma at the site of damage. After a traumatic injury, regenerating nerves may develop a painful swelling at the severed end. This development is often accompanied by significant pain along the affected nerve's distribution, which can, in some cases, be more debilitating than the loss of motor function or sensation. It has been hypothesized that a proximal nerve crush may offer therapeutic benefits for painful neuromas by altering the axonal growth pattern and disrupting retrograde signaling. Despite existing treatment approaches, success in managing neuromas has been limited. Therefore, it is crucial to deepen our understanding of painful neuromas and develop more effective therapies. The molecular mechanisms underlying the formation and pain associated with symptomatic neuromas remain poorly understood. In this study, we thoroughly characterize the transcriptional changes in the dorsal root ganglion at single-cell resolution following proximal nerve crush versus nerve resection after neuronal transection.

  单细胞
• Effect of tPA and Annexin A2 receptor inhibition on neutrophils gene expression after ischemic stroke
  GSE246580Rattus norvegicus9 个样本2026-10-29

  Acute ischemic stroke is a life-threating disease worldwide and tissue plasminogen activator (tPA) is currently the only drug approved for thrombolytic treatment. tPA has been reported to interact with neutrophils and have an impact on its activity. The project carried out the RNA sequencing on neutrophils, which aimed to investigate the mRNA expression change of neutrophils in response to tPA infusion and Annexin A2 receptor inhibition after ischemic stroke.
• Transcriptomic profiling of primary rat nucleus pulposus cells following MDL-800 treatment
  GSE337900Rattus norvegicus7 个样本2026-10-28

  Intervertebral disc degeneration is associated with age-related molecular and epigenetic alterations in nucleus pulposus (NP) cells. SIRT6 is an NAD⁺-dependent histone deacetylase implicated in chromatin regulation, DNA repair, and cellular homeostasis. MDL-800 is a selective allosteric activator of SIRT6. To investigate the transcriptional effects of SIRT6 activation, primary rat nucleus pulposus cells were treated with MDL-800 or vehicle control, and genome-wide RNA sequencing was performed. Differential gene expression analysis was used to identify transcriptional changes associated with pharmacological activation of SIRT6 in nucleus pulposus cells.
• ATAC-seq analysis of chromatin accessibility in rat nucleus pulposus cells following MDL-800 treatment
  GSE337792Rattus norvegicus6 个样本2026-10-28

  Intervertebral disc degeneration is associated with altered cellular homeostasis and epigenetic regulation. To investigate chromatin accessibility changes induced by SIRT6 activation, primary rat nucleus pulposus cells were treated with the SIRT6 activator MDL-800 and analyzed by ATAC-seq. Three biological replicates were generated for untreated control cells and MDL-800-treated cells. Raw sequencing data were deposited in the Sequence Read Archive (SRA), and processed differential chromatin accessibility results are provided.
• Tissue engineering polymeric formulations enable lymphangiogenesis for myocardial repair
  GSE330459Rattus norvegicus6 个样本2026-10-28

  We performed single-cell RNA sequencing (scRNA-seq) to profile the transcriptional landscape of ventricular tissue in a Sprague-Dawley rat model of myocardial ischemia/reperfusion (I/R). Two groups were analyzed: an I/R control group and a group treated with the pro-lymphangiogenic polymeric formulation PD-DN. Ventricular tissues were collected from both groups at three time points post-injury — 3, 5, and 7 days — to capture the temporal dynamics of cardiac repair. Single-cell suspensions were processed using the 10x Genomics Chromium platform with Illumina NovaSeq sequencing. Our analysis revealed temporally orchestrated changes in endothelial, immune, and fibroblast cell populations. The data provide insights into how PD-DN-driven lymphangiogenesis reprograms the cardiac microenvironment to facilitate functional recovery.

  单细胞
• YS-10 Exerts Therapeutic Effects on Radiation-Induced Testicular Damage
  GSE345816Rattus norvegicus9 个样本2026-10-27

  This study comparatively analyzed RNA‑sequencing data of rat testicular tissues from the control group, radiation‑induced injury model group, and treatment group